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Copy of a letter Rush composed to Jefferson regarding appointments Jefferson has made, as well as the impact of yellow fever epidemics on commerce with Europe.

Rush discusses his appointment to the Army, the support of doctors Shippen and Brower for that appointment, his concerns about the medical system and the numbers of deaths the army has experienced, dispatches that have arrived from France, and that John Adams is on his way there.

Rush writes a brief note to inform Julia that a friend has failed, physically.

Note by Rush requesting that no more books be lent to Mr. Dick on Dr. Rush's account, but permitting the bearer of the note to borrow any books required.

Rush writes most likely to Dr. Basil G. Middleton, (c. 1740-1818), a former surgeon with Virginia forces in the Revolutionary War, now living in London. Rush discusses personal and medical matters, touching on College of Philadelphia medical school classes and enrollment, and comments on the unconcluded treaty with England and the American political system.

Rush's copy of a letter to Hosack on the origin of the fortifications and other Native ruins in different parts of the country.

Rush congratulates Greene on his successes in North Carolina, then recommends that he move from Rhode Island to South Carolina, which is more active in manners and government and would suit him better. He then comments upon the country's need for Confederation and for a national character built upon something more than resentment of Great Britain.

Rush outlines a full course of treatment for an undefined equine disease, including bloodletting.

Rush rejoices in Read's recovery and safe return to South Carolina and sends greetings to Read's family. He outlines family news, including that Julia has given birth to another girl and Mrs. Boudinott has spent the winter. He adds that the women humanize their friend, Dr. Ramsay, in preparation for his finding a wife.

Rush writes a letter of introduction for University of Pennsylvania chemist, Dr. James Woodhouse.