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Rush explains his reasons for leaving the Reverend's church; he mentions Rev. Sproat.

Rush writes his memories of John Rodgers, the patriarch of Presbyterianism in the United States. Rodger's had been his boyhood friend at Dr. Finley's school in Maryland. In 1777, Rush had taken care of Rodger's son in Kingston following a battle.

Rush writes a more detailed letter regarding Mr. Carter's debts and ill treatment of Carter, who was insane, by his family. Includes a statement of charges certified by the hospital's steward. Letter features an additional written comment made by Henderson or someone in his firm.

Rush writes regarding a Mr. Carter's debts, particularly regarding his coffin and grave.

Rush writes to his son regarding his education. He expects him to study Latin and arithmetic, and stresses that he needs to pay more attention to his spelling.

Rush congratulates the unnamed recipient on his recent appointment in the army, and makes note of the support of France and Spain in America's revolutionary cause, along with other Mediterranean countries. He mentions that the army expects to check any advance of General Howe into Philadelphia, whose appearance would cause a panic. He notes that his opposition to Pennsylvania's current government has cost him his seat in Congress, but that he had planned to join the army in any case.

Rush makes treatment recommendations for an undisclosed ailment.

Rush records the benefits of using Kinepox over variolation to inoculate against smallpox.

Rush replies to a requested consult regarding a severe case of hemorrhoids or other bowel problem. He proposes that if the patient is willing to visit Philadelphia, the problem can be treated surgically.

Rush's draft letter acknowledges receipt of his certificate of membership in the Royal Academy of Medicine in Madrid, and laments the general lack of appreciation one experiences at the end of a career.