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Rush writes regarding the health of Julia's uncle's family, one of whom is suffering from a stomach disorder. He also notes that Julia's father's health is deteriorating. Her father will accompany him upon his return, to be placed under another physician's care. He requests that Julia have his assistants call upon the parents of children Rush inoculated before his departure, with instructions for their care. He describes the trial of a Dr. Shippen. He mentions that the letter was written in company, in General Green[e?]'s office.

Rush's copy of a letter assuring the Baron he has read all of the medical segments of Van Sach's letters from Surinam, regarding the origins of infectious disease, including yellow fever and influenza. He commends Van Sach on his plans for preventing fevers in Surinam.

Rush's copy of a letter he wrote regarding his memories of Dr. William Cullen.

Rush writes that deaths from fever are decreasing, and he will soon end his engagement with city hospital. He outlines activities in the family, and their preparations for her return the following week. The signature to this letter has been excised.

Rush reports that despite being exposed to the fever daily for two months, he is still healthy. However, he has "felt, mourned, and wept" until he could no longer do so. He reports that poor people chase him down in the street, and that he carries medicine with him in order to do all he can to help them. Free blacks and servants form a large percentage of his patients.

Copy of a letter Rush composed to Jefferson regarding appointments Jefferson has made, as well as the impact of yellow fever epidemics on commerce with Europe.

Rush discusses his appointment to the Army, the support of doctors Shippen and Brower for that appointment, his concerns about the medical system and the numbers of deaths the army has experienced, dispatches that have arrived from France, and that John Adams is on his way there.

Rush writes a brief note to inform Julia that a friend has failed, physically.

Note by Rush requesting that no more books be lent to Mr. Dick on Dr. Rush's account, but permitting the bearer of the note to borrow any books required.

Rush writes most likely to Dr. Basil G. Middleton, (c. 1740-1818), a former surgeon with Virginia forces in the Revolutionary War, now living in London. Rush discusses personal and medical matters, touching on College of Philadelphia medical school classes and enrollment, and comments on the unconcluded treaty with England and the American political system.