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Note by Rush requesting that no more books be lent to Mr. Dick on Dr. Rush's account, but permitting the bearer of the note to borrow any books required.

Rush writes most likely to Dr. Basil G. Middleton, (c. 1740-1818), a former surgeon with Virginia forces in the Revolutionary War, now living in London. Rush discusses personal and medical matters, touching on College of Philadelphia medical school classes and enrollment, and comments on the unconcluded treaty with England and the American political system.

Rush's copy of a letter to Hosack on the origin of the fortifications and other Native ruins in different parts of the country.

Rush congratulates Greene on his successes in North Carolina, then recommends that he move from Rhode Island to South Carolina, which is more active in manners and government and would suit him better. He then comments upon the country's need for Confederation and for a national character built upon something more than resentment of Great Britain.

Rush outlines a full course of treatment for an undefined equine disease, including bloodletting.

Rush rejoices in Read's recovery and safe return to South Carolina and sends greetings to Read's family. He outlines family news, including that Julia has given birth to another girl and Mrs. Boudinott has spent the winter. He adds that the women humanize their friend, Dr. Ramsay, in preparation for his finding a wife.

Rush writes to Thornton regarding his opposition to capital punishment, and encloses copies of a his pamphlet on the matter, of which Thronton had approved. Rush also discusses his birthplace, Byberry, where Thornton resides.

Rush thanks Dr. Bostock for his essay on respiration, saying he will read it with interest and awaits Bostock's future work on the topic. The rest of the letter relates to Rush's English ancestry and friendship with Bostock's father.

Rush thanks Bostock for his article "Analysis of Animal Fluides," then provides requested anecdotes regarding Bostock's father. Rush comments upon treatment for pulmonary consumption and the use of bloodletting in parturition and pregnancy.

Rush informs Julia that he has been thinking more of the children than he has in weeks and describes a dream he has had about her. He inquires after the new baby. He plans to ride out to the countryside to repair his health and later reports feeling stronger. He lists the conditions of those among their acquaintances.