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Rush congratulates Jones on his decision to leave Congress, and records his own regrets regarding public service, with particular regard to the funding system and the banks. He now believes American citizens "unfit for and undeserving of liberty."

Rush's brief note to his wife following her departure, enclosing 10 dollars and providing information on the family's health.

Rush recommends Dr. James Finley to McHenry, and requests that he visit Finley's patients with him. He adds that he is forced into a military retirement by Dr. Shippen's friends, but takes pleasure in McHenry's service. Finally, he comments on the alliance with France.

Rush states that he is never indifferent to any thing relating to America, and that the basis for America's freedom is broad, but is in danger from a tedious and expensive war, and from "the ignorance, indolence, and avarice of too many of our Whigs." He follows with questions regarding the country's finances, then notes that he has ordered a court-martial of Dr. Shippen, for whom he will serve as prosecutor. A postscript discusses two bills before Congress.

Rush notes that his pupil is better, and that he is using profuse sweating as part of his treatment for the fever. A later note was appended to the letter stating that Mrs. Rush allowed the signature to be cut away for an autograph.

Rush comments on commerce and the work of physicians, and on Philadelphia physicians opposed to use of mercury and bloodletting.

The diary records Rush's travel, accompanied by a servant and via horses, between the outskirts of Philadelphia and Carlisle, Pennsylvania, for an initial meeting with the trustees of Dickinson College. During the meeting the Trustees selected Dr. Charles Nisbet to serve as the College's first president. Rush described the taverns and other travel lodges at which he stopped, along with Tavern staff and other patrons, the quality of the food and drink, along with conversations he witnessed or took part in. Discussion often centered on the topics of the Constitution, paper money, as well as Dickinson College. Rush also described the results of a rapid Spring thaw on the Susquehanna River, the unusually cold weather, the scenery, and the presence whiskey stills in Irish settlements and their impact on their communities.

David Hosack acknowledges Julia Rush's letter and states that he has sent a keepsake in memory of his wife. He requests that she consider a visit to them.

Contains primarily accounts for individuals the Rush's employed in their household, including various house servants, cooks, coachmen, farmers and gardeners, along with accounts for work completed by washerwomen outside the residence. Individual accounts include the servant's name, followed by notes on pay and payments made, as well as any holds on pay, advances, loans, and pay rate increases. They also indicated when an individual was supplied with shoes or clothing, or had time off to visit the country. In addition, for the majority of the individuals, Benjamin continued his habit of adding a descriptive note when the person left their service, stating the reason for the departure, commenting on the quality of that servant's work, outlining their personal and work habits (especially their drinking habits), whether they married or not, and their race or ethnic background. Includes an incomplete alphabetical index for servant names. There are a few additional household accounts briefly noted, for wood and an umbrella, as well as two receipts, one for taxes and another (laid-in) for bread.

Pascalis acknowledges receipt of two essays. He states that he has not yet had the opportunity to read Dr. Rush's treatise on the diseases of the mind, but that he plans to write a review of it.