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Rush describes the funerals taking place in the city, and tells Julia that the fever has been particularly fatal to the young. He rejoices that the boys left the city, but hopes they avoid fatigue, heat, and cold, so that they do not excite any portion of the fever they might have carried with them from town. He expresses concern that the city is only at the beginning of the epidemic, but joins Julia in planning to express more gratitude for God's mercies in the future.

Rush briefly notes that the disease spreads, but mortality is not in proportion to the numbers afflicted. His cure is jalap and mercury, taken on the first day of the attack.

Rush notes that his pupil is better, and that he is using profuse sweating as part of his treatment for the fever. A later note was appended to the letter stating that Mrs. Rush allowed the signature to be cut away for an autograph.

Pickering notes that he sent Yellow Fever medicine developed by Dr. Conrad G. Bölke to the Board of Health, but is only now sending along copies of his letters from Bölke and the United States consul at Hamburg, Joseph Pitcairn, with instructions regarding the medicine's use.