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Rush makes treatment recommendations for an undisclosed ailment.

Rush's copy of a letter he wrote regarding his memories of Dr. William Cullen.

Rush writes a brief note to inform Julia that a friend has failed, physically.

Rush records the benefits of using Kinepox over variolation to inoculate against smallpox.

Rush explains his reasons for leaving the Reverend's church; he mentions Rev. Sproat.

In this letter to his sister, Rachel, Rush provides details of their sister Rebecca's death, his grief, and the state of their mother's health.

Rush comments on commerce and the work of physicians, and on Philadelphia physicians opposed to use of mercury and bloodletting.

Rush outlines a full course of treatment for an undefined equine disease, including bloodletting.

Rush writes about solitude, and how he misses having his wife and family to impart his thoughts and ideas to immediately.

Rush asks that Julia and the children mourn his sister's death, as he is doing. He is unable to see patients because of continued weakness.