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Includes a few medical statements and receipts, along with two volumes of household accounts maintained by Benjamin Rush, one in conjunction with his wife. Along with general expenses and accounting information, the account books feature the employment records for Rush family staff and servants, often containing comments on the character and notable aspects of the employment history of each employee.

The majority of the 136 letters in the series were composed by Benjamin Rush, and letters he wrote to Julia during the 1793 yellow fever epidemic in Philadelphia form a substantial part of the series. Main topics in the letters include Rush family matters, medical treatments for a wide variety of medical issues, American politics, and the country's relations with European nations. Other topics include mental illness and its treatment, the medical department in the Continental Army, the impact of epidemics upon commerce internationally, reading habits, parenting, and capital punishment.

Contains a medical case book and a fragment of an essay or lecture written by Benjamin Rush, along with his travel diary for a trip to meet with the Board of Trustees for Dickinson College in 178[4]. Other materials include Julia Rush's devotional journal and exercise book, as well as an undated presentation note written by Richard Rush.