Dickinson writes that he has purchased and perused all the doctor's works and requests his help in diagnosing and treating a child that is in excruciating pain.
Dickinson writes that he has read with pleasure Rush's essay on female education. He requests Rush's help with another project, "to prepare the public Mind for receiving…the proceedings of the Convention."
Adams writes regarding his presenting a copy of Rush's "Medical Inquiries and Observations" to the Emperor of Russia, who is sending Rush a ring in thanks.
Greene writes of his support for Rush's recommendations regarding best methods for preserving the health of the Army. He suggests they print a pamphlet on the topic, to make adoption of the recommendations more likely. He comments on Congress' regulation of hospitals.
Henderson replies to Rush's letter regarding the debts of a Mr. Carter, assuring Rush that he is in error, all costs for the preparation of coffin and grave have been paid.
Jefferson discusses vaccinations in Philadelphia, the impact of his sending a message rather than making a speech at the opening of Congress, the political implications of suppressing taxes, and his desire to live a long, healthy, and useful life.
Jefferson notes that he has appointed Dr. Waterhouse to the Marine hospital in Boston, in return for his introducing vaccinations to the country, and describes the political fallout from the appointment. He plans to send his 15-year-old grandson to be with Rush in the Fall. He mentions Dr. Rose, and the impact on an embargo on relations with Europe.
Pickering notes that he sent Yellow Fever medicine developed by Dr. Conrad G. Bölke to the Board of Health, but is only now sending along copies of his letters from Bölke and the United States consul at Hamburg, Joseph Pitcairn, with instructions regarding the medicine's use.