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Rush writes a letter of introduction for University of Pennsylvania chemist, Dr. James Woodhouse.

Rush explains his reasons for leaving the Reverend's church; he mentions Rev. Sproat.

Paine recommends a candidate for the midwifery position on the faculty at the University of Pennsylvania.

Rush's copy of a letter to a Mr. Harris regarding Rush's ability to establish a patent for land in Lewistown.

In this letter to his sister, Rachel, Rush provides details of their sister Rebecca's death, his grief, and the state of their mother's health.

Rush comments on commerce and the work of physicians, and on Philadelphia physicians opposed to use of mercury and bloodletting.

Rush outlines a full course of treatment for an undefined equine disease, including bloodletting.

Rush writes about solitude, and how he misses having his wife and family to impart his thoughts and ideas to immediately.

Rush asks that Julia and the children mourn his sister's death, as he is doing. He is unable to see patients because of continued weakness.

Rush says that distress increases in Philadelphia, and names several friends and one doctor who have died.