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Pickering describes symptoms for which he would like Rush's treatment advice. Includes Rush's own notes regarding two prescriptions he advised.

Wayne describes his fever and consumption and their treatment, following his loss of blood "in defence of the rights & liberties of America, 'from her coldest, to her hottest sun.'"

Note by Rush requesting that no more books be lent to Mr. Dick on Dr. Rush's account, but permitting the bearer of the note to borrow any books required.

Rush's copy of a letter to Hosack on the origin of the fortifications and other Native ruins in different parts of the country.

Rush announces that the publication about the fever has been well received by the citizens. He updates Julia on the condition of several patients.

Rush recounts all the improvements he has made for her at Sydenham. He will begin sending the family from town with the warm weather in May or June.

Rush's draft letter acknowledges receipt of his certificate of membership in the Royal Academy of Medicine in Madrid, and laments the general lack of appreciation one experiences at the end of a career.

Rush describes his parting with their son, James, and announces that Dr. Coxe has been appointed Professor of Chemistry. Includes a letter from Samuel Rush to his mother.

Rush outlines how the family spent July 4th for Julia, then discusses possible successors to University of Pennsylvania chemist, James Woodhouse. Letter includes a poem by William Rush to his mother.

Rush writes to his son regarding his education. He expects him to study Latin and arithmetic, and stresses that he needs to pay more attention to his spelling.