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Dickinson writes that he has read with pleasure Rush's essay on female education. He requests Rush's help with another project, "to prepare the public Mind for receiving…the proceedings of the Convention."

Rush points out that he is too weak and busy to ride out to her at Rosehill, but she may come in to town, or he will ride out to spend the next day with her.

Rush writes that he is preparing for the "awful duties of the day," as yesterday exceeded any of the preceding days in distress and death, and two more physicians are ill.

Rush enumerates the close family friends that are ill or have died, and notes that only one doctor who continues to follow his treatment.

Rush announces that his pupil, Johnny Stall, has died. He mentions that citizens universally exhibit symptoms of the fever, but that the poor suffer the most. He hopes the weather will change.

Rush notes that both boys have headaches, but are travelling regardless. He reports on the fever in their neighborhood, listing who has died or left town.

Madison writes regarding quarantine laws in Europe and their impact on commerce with the United States, with reference to yellow fever in particular.

Adams writes regarding his presenting a copy of Rush's "Medical Inquiries and Observations" to the Emperor of Russia, who is sending Rush a ring in thanks.

Rush's copy of a letter assuring the Baron he has read all of the medical segments of Van Sach's letters from Surinam, regarding the origins of infectious disease, including yellow fever and influenza. He commends Van Sach on his plans for preventing fevers in Surinam.

Rush writes to Thornton regarding his opposition to capital punishment, and encloses copies of a his pamphlet on the matter, of which Thronton had approved. Rush also discusses his birthplace, Byberry, where Thornton resides.